Parathyroid carcinoma is a rare endocrine malignant neoplasm and accounts for less than 1% of all cases of primary hyperparathyroidism. Clinical features of parathyroid carcinoma are primarily owing to the excessive secretion of parathyroid hormone (PTH) rather than to tumor burden. Nonfunctioning parathyroid carcinomas are exceedingly rare. Distant metastases typically occur late and in about one-third of patients.1 Neck nodes, lung, liver, and bone are most commonly involved. Surgical tumor removal is the first-line treatment to avoid the potentially lethal complication of hypercalcemia.1
Morand GB, Rupp NJ, Huellner MW, et al. Transnasal-Transpterygoid Endoscopic Removal of an 18F–Choline-Avid Parathyroid Carcinoma Metastasis in the Skull Base. JAMA Otolaryngol Head Neck Surg. 2019;145(10):978–980. doi:10.1001/jamaoto.2019.2352
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