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Observation
August 22, 2019

Transnasal-Transpterygoid Endoscopic Removal of an 18F–Choline-Avid Parathyroid Carcinoma Metastasis in the Skull Base

Author Affiliations
  • 1Department of Otorhinolaryngology–Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland
  • 2University of Zurich, Zurich, Switzerland
  • 3Institute of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland
  • 4Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
  • 5Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland
JAMA Otolaryngol Head Neck Surg. 2019;145(10):978-980. doi:10.1001/jamaoto.2019.2352

Parathyroid carcinoma is a rare endocrine malignant neoplasm and accounts for less than 1% of all cases of primary hyperparathyroidism. Clinical features of parathyroid carcinoma are primarily owing to the excessive secretion of parathyroid hormone (PTH) rather than to tumor burden. Nonfunctioning parathyroid carcinomas are exceedingly rare. Distant metastases typically occur late and in about one-third of patients.1 Neck nodes, lung, liver, and bone are most commonly involved. Surgical tumor removal is the first-line treatment to avoid the potentially lethal complication of hypercalcemia.1

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