Spitz tumors are melanocytic lesions that span the spectrum from benign Spitz nevi to malignant Spitz melanomas with potential for widespread metastasis.1,2 The classification of “atypical Spitz tumors” (ASTs) describes the heterogeneous body between these 2 extremes, loosely defined as having 1 or more atypical features not characteristic of benign Spitz nevi.1,2 Although local recurrence and spread to regional lymph nodes is common,3,4 ASTs do not usually metastasize or affect patient survival.4 However, in the absence of clear markers that reliably distinguish them from malignant melanomas,5 ASTs pose a unique diagnostic and treatment challenge.
Pham TB, Tucker S, Nation J. Atypical Spitz Tumor of the Lower Lip in a Pediatric Patient. JAMA Otolaryngol Head Neck Surg. 2020;146(2):203–205. doi:10.1001/jamaoto.2019.3385
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