[Skip to Navigation]
Views 801
Citations 0
Comment & Response
November 27, 2019

Sudden Sensorineural Hearing Loss

Author Affiliations
  • 1Department of Medical Sciences, University of Torino Corso AM Dogliotti 14, 10126 Torino, Italy
  • 2Division of Otorhynolaryngology, University of Turin, Hospital San Luigi Gonzaga, Regione Gonzole, Orbassano, Torino, Italy
  • 3Department of Biotechnology Chemistry & Pharmacy, University of Siena, Siena, Italy
JAMA Otolaryngol Head Neck Surg. 2020;146(2):211. doi:10.1001/jamaoto.2019.3662

To the Editor We praise the article by Bayoumy et al,1 who stressed the importance of oxygen supply for the amelioration of sudden sensorineural hearing loss (SSNHL). We reported that of patients with SSNHL attending an otorhinolaryngology clinic in Torino, Italy, 94.4% (odds risk, 13.6%) had an infection by a known ischemia inducing agent (ie, Helicobacter pylori).2 In addition, this pathogen may cause thrombosis via a number of mechanisms, the best known of which is antigenic mimicry (ie, the production of autoantibodies against a variety of human antigens that share an amino acid linear homology with bacterial epitopes). Particularly worthy of mention are autoantibodies against phospholipids, which will disappear after cure of the infection3; against platelets—with the known consequence of autoimmune thrombotic thrombocythemia4—and against endothelial cells5 that are also directly activated by the bacterium. In addition, H pylori elicits neutrophilic infiltration, a cause of neutrophilic extracellular traps because the bacterium secretes a neutrophilic-activating protein. Neutrophilic infiltration of vascular walls may lead to venous thrombosis. Detection and cure of this infection is not expensive and is available worldwide. We propose that the search of H pylori infection and treatment of positive cases could ameliorate SSNHL outcomes in many patients, at least in countries with high circulation of this pathogen.

Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words