Scleroderma is a relative contraindication in the treatment of patients with radiotherapy given its potential for increased acute and late toxic effects.1-3 There is a paucity of data regarding the clinical implications of scleroderma in patients with larynx cancer (LC) who pursue organ-preserving radiotherapy (RT).4 We present 2 cases of patients with LC and scleroderma who were treated with RT that resulted in disparate adverse effects to illustrate the importance of considering the benefits of organ preservation against potential life-threatening toxic effects in this patient cohort.
Rydzewski NR, Harari PM, Hartig GK, Francis D, Witek ME. Clinical Implications of Scleroderma in the Decision for Radiotherapy-Based Larynx Preservation. JAMA Otolaryngol Head Neck Surg. 2020;146(3):308–309. doi:10.1001/jamaoto.2019.3911
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