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December 12, 2019

Clinical Implications of Scleroderma in the Decision for Radiotherapy-Based Larynx Preservation

Author Affiliations
  • 1Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Carbone Cancer Center, Madison
  • 2Division of Otolaryngology and Head and Neck Surgery, Department of Surgery, School of Medicine and Public Health, University of Wisconsin, Carbone Cancer Center, Madison
JAMA Otolaryngol Head Neck Surg. 2020;146(3):308-309. doi:10.1001/jamaoto.2019.3911

Scleroderma is a relative contraindication in the treatment of patients with radiotherapy given its potential for increased acute and late toxic effects.1-3 There is a paucity of data regarding the clinical implications of scleroderma in patients with larynx cancer (LC) who pursue organ-preserving radiotherapy (RT).4 We present 2 cases of patients with LC and scleroderma who were treated with RT that resulted in disparate adverse effects to illustrate the importance of considering the benefits of organ preservation against potential life-threatening toxic effects in this patient cohort.

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