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In This Issue of JAMA Otolaryngology
December 2019


JAMA Otolaryngol Head Neck Surg. 2019;145(12):1097. doi:10.1001/jamaoto.2018.2813

In this cohort study, Cramer et al assess the performance of the traditional pathologic risk stratification system for surgically resected human papillomavirus (HPV)–associated oropharyngeal squamous cell carcinoma (OPSCC) and propose a novel composite risk stratification system. Using the National Cancer Database, the authors identified 15 324 patients diagnosed with nonmetastatic head and neck squamous cell carcinoma (HNSCC) who were treated with upfront surgery and neck dissection. They compared traditional pathologic risk stratification for HPV+ OPSCC and HPV-unassociated HNSCC and derived a novel pathologic risk stratification system.