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Comment & Response
April 2, 2020

Detection and Implications of Occult Contralateral Nodal Spread in Human Papillomavirus–Associated Base of Tongue Cancer

Author Affiliations
  • 1Department of Radiation Oncology, Emory University School of Medicine, Atlanta, Georgia
JAMA Otolaryngol Head Neck Surg. 2020;146(6):586-587. doi:10.1001/jamaoto.2020.0316

To the Editor We congratulate Last et al1 for their valuable contribution to our understanding of the risk of contralateral nodal spread in patients with human papillomavirus (HPV)–associated squamous cell carcinoma of the base of the tongue. They report occult contralateral nodal involvement in 21.4% of the cohort and appropriately argue that this warrants bilateral neck management in patients with this disease. We have 2 questions that would be relevant to the head and neck oncology community.

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