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Observation
May 21, 2020

Persistent Laryngeal Swelling Caused by Primary Intralymphatic Histiocytosis

Author Affiliations
  • 1Departments of Internal Medicine and Immunology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands
  • 2Leiden University Medical Center, Leiden, the Netherlands
  • 3Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands
  • 4Department of Pathology, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands
  • 5Department of Otorhinolaryngology, Franciscus Gasthuis & Vlietland, Rotterdam, the Netherlands
  • 6Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands
JAMA Otolaryngol Head Neck Surg. Published online May 21, 2020. doi:10.1001/jamaoto.2020.0849

Early recognition and treatment of laryngeal swelling is essential owing to the potential life-threatening upper airway obstruction. Moreover, chronic laryngeal swelling may be caused by malignant or inflammatory conditions, such as amyloidosis,1 sarcoidosis,2 or IgG4-related disease.3 Here, we report a case with persistent laryngeal swelling caused by primary intralymphatic histiocytosis (ILH), a very rare benign disease that usually presents cutaneously.4,5

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