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Observation
August 27, 2020

Facial Nerve Intraneural Perineurioma Masquerading as a Schwannoma

Author Affiliations
  • 1Department of Otolaryngology−Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee
  • 2Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee
  • 3Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee
JAMA Otolaryngol Head Neck Surg. 2020;146(10):970-972. doi:10.1001/jamaoto.2020.2098

Schwannomas are the most common benign tumors of the intratemporal facial nerve (FN). Treatment options include observation or intervention (radiation or surgery) in case of persistent growth or decline of facial nerve function.1 Intraneural perineurioma (INP) is a rare tumor that usually arises in the peripheral motor nerve and causes focal neuropathy.2 Histologically it is distinct from other peripheral nerve sheath tumors and other inflammatory processes. Intrinsic INP involving the facial nerve is rare, with prior reports of lesions involving the descending segment of FN.3,4 We report a multisegmental INP that caused progressive facial weakness and radiologically mimicked a schwannoma.

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