Surgery for primary hyperparathyroidism (pHPT) is usually highly rewarding both for the surgeon and for the patient. Successful parathyroid surgery cures the disease1 and improves kidney and skeletal function.2 Finding the diseased gland(s) can be difficult, however, and even high-volume, experienced surgeons are sometimes unable to cure their patients.3 Accurate preoperative localization improves outcomes, shortens operation times, and simplifies operation room planning.3 Yet, there is still no imaging modality that in all patients identifies all diseased parathyroid glands. In the meta-analysis by Lee et al,4 positron emission tomography with the radiotracer 18F-fluoromethyl-dimethyl-2-hydroxyethyl-ammonium combined with positron emission tomography and computed tomography (FCH PET/CT) was demonstrated to have superior accuracy in identifying diseased parathyroid glands, both on the lesion and on the patient level.
Identify all potential conflicts of interest that might be relevant to your comment.
Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.
Err on the side of full disclosure.
If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.
Not all submitted comments are published. Please see our commenting policy for details.
Almquist M. Localization Studies for Parathyroid Surgery. JAMA Otolaryngol Head Neck Surg. 2021;147(8):706–707. doi:10.1001/jamaoto.2021.0999
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: