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Clinical Note
January 2000

Thalidomide for the Treatment of Acquired Immunodeficiency Syndrome–Associated Refractory Oral Ulcers

Author Affiliations

From the Special Needs Unit, School of Medicine and Dentistry, Santiago de Compostela University, Santiago de Compostela (Dr Diz Dios), and the Section of Infectious Diseases, Department of Internal Medicine (Drs Sopeña, Crespo, and Ocampo), and Department of Pathology (Drs Cameselle and Butrón), Xeral-Cíes Hospital, Vigo, Spain.

Arch Otolaryngol Head Neck Surg. 2000;126(1):89-92. doi:10.1001/archotol.126.1.89

A case of severe, oral, not otherwise specified ulcers in a human immunodeficiency virus–infected patient is described. The lesions did not respond to acyclovir, prednisone, pentoxifylline, or foscarnet sodium therapy. Dramatic clinical improvement and progressive ulcer healing were observed after starting oral thalidomide therapy. Clinicians should be aware of the usefulness of thalidomide for the treatment of acquired immunodeficiency syndrome–associated not otherwise specified ulcerations.

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