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Pathology Forum
July 2000

Quiz Case 2

Arch Otolaryngol Head Neck Surg. 2000;126(7):901-906. doi:

Fibromatosis, which is a benign but aggressive proliferation of fibroblastic cells, occasionally presents in the head and neck. It belongs to a family of fibrous proliferative disorders, including plantar fibromatosis (Dupuytren disease), palmar fibromatosis (Ledderhose disease), penile fibromatosis (Peyronie disease), abdominal fibromatosis, and intra-abdominal fibromatosis.1 In fibromatosis, the proliferating fibroblastic cells are derived from fascia and aponeuroses. These cells tend to extend along fascial planes and aggressively infiltrate adjacent muscle.2 They occur most commonly in the anterior abdominal wall (abdominal desmoid tumor) but have been reported in a variety of anatomical locations outside the abdomen (extra-abdominal desmoid).

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