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Pathology Forum
November 2000

Quiz Case 1

Arch Otolaryngol Head Neck Surg. 2000;126(11):1390-1393. doi:

Kaposi sarcoma is the most common malignancy in acquired immunodeficiency syndrome (AIDS), followed by non-Hodgkin lymphoma.1 Kaposi sarcoma is an AIDS-defining illness that occurs in about 15% of patients with AIDS, 95% of whom are homosexual or bisexual men. Its high prevalence in this risk group supports the role of a sexually transmittable agent. In fact, there is strong evidence associating KS with human herpesvirus 8.2 The incidence of KS is now decreasing, which is probably a reflection of safer sexual practices among the homosexual community. Besides the epidemic form associated with HIV infection and AIDS, KS occurs very rarely in 3 other epidemiological forms: (1) a classic or sporadic form, seen in elderly white men of Mediterranean or Ashkenazic Jewish descent; (2) an endemic form, seen in some parts of equatorial Africa; and (3) a form associated with renal transplantation.2

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