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Clinical Problem Solving: Pathology
April 2008

Pathology Quiz Case 1: Diagnosis

Author Affiliations


Arch Otolaryngol Head Neck Surg. 2008;134(4):448. doi:10.1001/archotol.134.4.448-a

The differential diagnosis of oncocytic neoplasms of salivary glands includes both primary and metastatic tumors.1Oncocytic cells have small, round, centrally placed nuclei with abundant granular eosinophilic or clear cytoplasm that demonstrates numerous mitochondria on ultrastructural examination.2The most frequent primary oncocytic neoplasm is oncocytoma, which represents fewer than 1% of salivary gland tumors and is most common in the parotid gland. Other parotid neoplasms containing oncocytic cells include Warthin tumor (the second most common benign neoplasm of the salivary glands) and oncocytic carcinoma. There are also other nonneoplastic conditions associated with oncocytic cells, eg, oncocytic metaplasia and nodular and diffuse oncocytic hyperplasia.

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