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Clinical Note
July 21, 2008

Diffuse Intranasal Papillomatosis and Its Association With Human Papillomavirus

Author Affiliations

Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2008

Arch Otolaryngol Head Neck Surg. 2008;134(7):778-780. doi:10.1001/archotol.134.7.778

Intranasal papillomas may be categorized by histologic origin as those arising from squamous or schneiderian epithelium. Squamous papillomas result from a proliferation of squamous epithelium into exophytic papillary fronds, are almost exclusively unilateral, and are usually pedicled in the nasal vestibule. Bilateral diffuse intranasal squamous papillomatosis represents a poorly described variant of this disease, which may represent a distinct pathologic process derived from an underlying human papillomavirus (HPV) infection, and its treatment should address this etiology. We report on 2 rare cases of diffuse intranasal papillomatosis and discuss their presentation, workup, HPV characterization, and treatment.

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