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Clinical Note
July 21, 2008

Diffuse Intranasal Papillomatosis and Its Association With Human Papillomavirus

Author Affiliations

Author Affiliations: Departments of Otorhinolaryngology–Head and Neck Surgery (Drs Bleier, Gawthrop, Thaler, Sewell, and Chiu and Mr Marvel) and Pathology and Laboratory Medicine (Dr Montone), The University of Pennsylvania School of Medicine, Philadelphia.

Arch Otolaryngol Head Neck Surg. 2008;134(7):778-780. doi:10.1001/archotol.134.7.778

Intranasal papillomas may be categorized by histologic origin as those arising from squamous or schneiderian epithelium. Squamous papillomas result from a proliferation of squamous epithelium into exophytic papillary fronds, are almost exclusively unilateral, and are usually pedicled in the nasal vestibule. Bilateral diffuse intranasal squamous papillomatosis represents a poorly described variant of this disease, which may represent a distinct pathologic process derived from an underlying human papillomavirus (HPV) infection, and its treatment should address this etiology. We report on 2 rare cases of diffuse intranasal papillomatosis and discuss their presentation, workup, HPV characterization, and treatment.

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