Intranasal papillomas may be categorized by histologic origin as those arising from squamous or schneiderian epithelium. Squamous papillomas result from a proliferation of squamous epithelium into exophytic papillary fronds, are almost exclusively unilateral, and are usually pedicled in the nasal vestibule. Bilateral diffuse intranasal squamous papillomatosis represents a poorly described variant of this disease, which may represent a distinct pathologic process derived from an underlying human papillomavirus (HPV) infection, and its treatment should address this etiology. We report on 2 rare cases of diffuse intranasal papillomatosis and discuss their presentation, workup, HPV characterization, and treatment.