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Clinical Problem Solving: Pathology
February 16, 2009

Pathology Quiz Case 2: Diagnosis

Author Affiliations


Arch Otolaryngol Head Neck Surg. 2009;135(2):216-220. doi:10.1001/archoto.2008.543-b

Diagnosis: Intramuscular myxoma of the stapedius muscle

The term myxomawas first used by Virchow1in 1863 to describe tumors that histologically resembled the mucinous connective tissue of the umbilical cord, named Whartonjelly. Later, in 1948, Stout2established specific criteria to define a true myxoma from other lesions that demonstrate similar myxoid characteristics. Specifically, he defined myxomas as nonmetastasizing mesenchymal neoplasms composed of stellate cells in a loose connective tissue matrix.