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Clinical Note
June 2009

Cutaneous Colocalized Invasive Poorly Differentiated Carcinoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma of the Head and Neck Region: A Case Report and Review of the Literature

Author Affiliations

Author Affiliations: Department of Pathology, The University of Texas Southwestern Medical Center at Dallas.

Arch Otolaryngol Head Neck Surg. 2009;135(6):606-610. doi:10.1001/archoto.2009.51

Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is the most common form of chronic leukemia in the United States and Europe.1 It has been associated with an increased incidence of a second neoplasia, including carcinomas in various parts of the body. For example, in large population-based studies2,3 of solid tumors in patients with CLL/SLL, markedly increased risks were observed for Kaposi sarcoma, malignant melanoma, and carcinomas of the larynx and the lung. In contrast, occurrence of either synchronous (coexisting) or dyssynchronous (subsequent) poorly differentiated carcinoma and CLL/SLL in the skin is extremely rare. There are, so far, only limited single case reports in the literature.4 The case reported herein is another rare example of a cutaneous colocalized invasive poorly differentiated carcinoma and CLL/SLL of the head and neck region.