Leiomyosarcoma (LMS) is a rare soft-tissue cancer of the head and neck, accounting for 1% to 2% of nasal cavity and paranasal sinus tumors. It is more commonly found in the gastrointestinal or genitourinary tract. Leiomyosarcoma of the head and neck is associated with a history of radiation therapy, retinoblastoma, chemotherapy, human immunodeficiency virus, or AIDS. We describe what we believe is the first case of an LMS of the sphenoid sinus in the English-language literature and include a review of the literature on LMS of the paranasal sinuses, which identified approximately 50 cases of primary sinonasal LMS.
Ramakrishnan VR, Said S, Kingdom TT. Primary Leiomyosarcoma of the Sphenoid Sinus. Arch Otolaryngol Head Neck Surg. 2009;135(9):949–952. doi:10.1001/archoto.2009.114
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