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Clinical Note
September 2009

Primary Leiomyosarcoma of the Sphenoid Sinus

Author Affiliations

Author Affiliations: Departments of Otolaryngology (Drs Ramakrishnan and Kingdom) and Pathology (Dr Said), University of Colorado Denver Health Sciences Center.

Arch Otolaryngol Head Neck Surg. 2009;135(9):949-952. doi:10.1001/archoto.2009.114

Leiomyosarcoma (LMS) is a rare soft-tissue cancer of the head and neck, accounting for 1% to 2% of nasal cavity and paranasal sinus tumors. It is more commonly found in the gastrointestinal or genitourinary tract. Leiomyosarcoma of the head and neck is associated with a history of radiation therapy, retinoblastoma, chemotherapy, human immunodeficiency virus, or AIDS. We describe what we believe is the first case of an LMS of the sphenoid sinus in the English-language literature and include a review of the literature on LMS of the paranasal sinuses, which identified approximately 50 cases of primary sinonasal LMS.