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Clinical Problem Solving: Pathology
October 2009

Pathology Quiz Case 2: Diagnosis

Author Affiliations


Arch Otolaryngol Head Neck Surg. 2009;135(10):1056-1060. doi:10.1001/archoto.2009.125-b

Rhabdomyomas are rare benign tumors with striated muscle cell differentiation that are classified as either cardiac or extracardiac. Cardiac rhabdomyomas are believed to be hamartomatous lesions and are most often found in the hearts of children with tuberous sclerosis.1Extracardiac rhabdomyomas are well-differentiated neoplasms that are clinically and morphologically divided into adult, fetal, genital, and rhabdomyomatous hamartoma types.2Adult rhabdomyomas predominantly occur in elderly men (median age, 60 years; male to female ratio, 3:1), and 90% are located in the head and neck.2While adult head and neck rhabdomyomas are usually solitary tumors, 25% of cases are multinodular, with small nests of tumor in adjacent tissue, and 5% are multifocal.3