[Skip to Navigation]
Clinical Note
April 2001

Graft-vs-Host Disease as a Cause of Enlargement of the Epiglottis in an Immunocompromised Child

Author Affiliations

From the Departments of Otorhinolaryngology (Drs de Diego, Prim, del Palacio, and Rabanal) and Pathology (Dr Hardisson), La Paz Hospital, Autonomous University of Madrid, Madrid, Spain.

Arch Otolaryngol Head Neck Surg. 2001;127(4):439-441. doi:10.1001/archotol.127.4.439

We report a rare case of dyspnea due to enlargement of the epiglottis in a severely immunocompromised patient. The child underwent a previous tracheostomy at another hospital because of respiratory distress under the diagnosis of acute epiglottitis. The patient was subsequently decannulated without incident. One year later, the child developed a new episode of dyspnea with inspiratory stridor. A new tracheostomy was neccessary, and a biopsy specimen of the enlarged epiglottis was taken to confirm the diagnosis of graft-vs-host disease. The therapeutic measures in these situations are discussed below, and a review of the current literature concerning the etiology and management of epiglottic enlargement is performed.

Add or change institution