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Clinical Challenges
December 2001

Are Second-Generation Antihistamines Appropriate for Most Children and Adults?

Author Affiliations




Arch Otolaryngol Head Neck Surg. 2001;127(12):1510-1514. doi:10.1001/archotol.127.12.1510

Use of second rather than first-generation antihistamines for allergy symptoms is appropriate for most children and adults.

Antihistamines of the histamine1 (H1) type, which have been in clinical use for more than 50 years, are now being used by millions of Americans—perhaps 30 million or more.1,2 The main reason for their widespread use is to alleviate the symptoms associated with histamine-mediated allergies. The H1 antihistamines alleviate common symptoms by blocking H1 receptors on peripheral blood vessels and nerves, as well as in the frontal and temporal cortex.3

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