Leiomyosarcoma is a malignant tumor that rarely involves the region of the head and neck. In the head and neck, leiomyosarcomas arise from the smooth muscle of vessel walls, the erector pili musculature, the posterior wall of the trachea, or the muscular wall of the middle and lower thirds of the esophagus.1 In our review of the English-language literature, we found only 27 cases of leiomyosarcoma of the larynx.1-6 We report the case of a small leiomyosarcoma involving the middle third of the right vocal cord.