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Clinical Problem Solving: Pathology
May 2002

Diagnosis Pathology Quiz Case 2

Author Affiliations


Arch Otolaryngol Head Neck Surg. 2002;128(5):594-595. doi:

The clinical differential diagnosis of a tracheal mass includes nonneoplastic (eg, sarcoidosis and tuberculosis) and neoplastic (eg, hemangioma, chondroma, rhabdomyosarcoma, squamous cell carcinoma, granular cell tumor, and alveolar soft part sarcoma) diseases.1 A biopsy specimen of the mass demonstrated a collection of round cells with a nested growth pattern and vesicular nuclei within the submucosa (Figure 3). High-power magnification of the specimen revealed that the cells had a granular cytoplasm without a distinct cell border (Figure 4). Immunohistochemical studies showed that the tumor cells were postive for S100 protein and negative for cytokeratin.

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