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Clinical Problem Solving: Pathology
October 2002

Diagnosis Pathology Quiz Case 1

Author Affiliations


Arch Otolaryngol Head Neck Surg. 2002;128(10):1211-1212. doi:

First described in 1959, mesenchymal chondrosarcoma is a rare subtype of chondrosarcomas, making up only 3% to 9% of all chondrosarcomas.1 It arises from both skeletal and extraskeletal sites but has a predilection for the head and neck.1,2 Skeletal tumors outnumber extraskeletal tumors by a ratio of 2:1. Within the head and neck, skeletal sites most commonly include the maxilla and mandible; extraskeletal sites include the orbits and meninges. Most patients are in their second or third decade of life when the diagnosis is made; however, cases have been reported in infants and the elderly. There is a slight male predilection, with a ratio of 4:3. Mesenchymal chondrosarcoma of the maxilla has an aggressive local behavior as well as a high metastatic potential. There has recently been an increase in the number of reports of mesenchymal chondrosarcoma, presumably because of an increased knowledge of the tumor among clinicians and pathologists.3-6

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