FREDERIC B.ASKINMDWILLIAM H.WESTRAMD
Clinical manifestations of nasal T/NK-cell lymphomas may simulate those of other disease entities, and inadequate nasal biopsies may lead to nonspecific histopathologic pictures; therefore, early diagnosis of these lymphomas is a real challenge for both otolaryngologists and pathologists. Nasal T/NK-cell lymphomas usually present as extremely destructive lesions over the nasal cavities, paranasal sinuses, or nasopharynx, showing a necrotic and angioinvasive histopathologic pattern. In the past, they were included under the nebulous and descriptive term lethal midline granuloma.1 With the advance of immunohistochemical analysis and a growing understanding of sinonasal lymphomas, nasal T/NK-cell lymphomas could be distinguished from other groups of lethal midline granulomas, including infectious (such as tuberculosis) and noninfectious (such as WG) lesions.2
Pathology Quiz Case—Diagnosis. Arch Otolaryngol Head Neck Surg. 2003;129(10):1136. doi:10.1001/archotol.129.10.1135
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