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Clinical Note
July 2006

Mycosis Fungoides: A Case of Tonsil Involvement

Author Affiliations

Author Affiliations: Departments of Otolaryngology–Head and Neck Surgery, New York University School of Medicine, New York, NY (Drs Le and Lee and Ms Setlur), and The University of Texas M. D. Anderson Cancer Center, Houston (Dr Sikora).

Arch Otolaryngol Head Neck Surg. 2006;132(7):794-796. doi:10.1001/archotol.132.7.794

Systemic diseases often have varied otolaryngologic manifestations. Mycosis fungoides is a T-cell lymphoma that is often limited to cutaneous involvement but has occasional systemic spread. Careful physical examination and appropriate laboratory studies are keys to establish the diagnosis. We present a case of this unusual entity involving the oropharynx.

A 36-year-old man with a 4-year history of mycosis fungoides stage IIB presented to the otolaryngology clinic in January 2005 with a 1-month history of throat pain. He had initially presented with cutaneous lesions in June 2000, and immunohistochemical analysis of a skin shave biopsy specimen obtained at that time confirmed a diagnosis of mycosis fungoides with CD4+, CD8 cell markers. He was treated with a 3-month regimen of bexarotene (Targretin) and interferon, which resulted in hyperlipidemia and hypothyroidism. The cutaneous lesions persisted, and the patient underwent therapy with interferon and psoralen–UV-A for residual disease in February 2001.

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