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Poster Presentations: American Head and Neck Society
August 2006

P060 Significance of Insulinlike Growth Factor Receptor I in the Development of Anaplastic Thyroid Cancer

Arch Otolaryngol Head Neck Surg. 2006;132(8):877. doi:10.1001/archotol.132.8.877-b

Objective: To determine if loss of expression of phospho–insulinlike growth factor (p-IGF) receptor IGF IR in human thyroid cancer specimens correlates with progression to anaplastic disease and responsiveness to anti–IGF-IR therapy.

Design: Retrospective histopathologic study with institutional review board approval

Subjects: Expression levels of IGF-I, pIGF-IR, IGF-IR, Akt, and pAKT were evaluated in 36 thyroid cancer specimens, 6 normal thyroid glands, and thyroid tissue arrays using an immunoperoxidase assay.

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