Head and Neck Surgery Unit, Liverpool, England;
University of Liverpool
Background:CYGB is a candidate tumor-suppressor gene on chromosome 17q and is the only gene completely contained within the 42.5-kilobase tylosis with esophageal cancer minimal region. This region is subject to frequent deletions in sporadic esophageal cancer; however, no coding mutations have been demonstrated in patients affected with tylosis. Cytoglobin is a recently described, intracellular globin whose role in cancer is as yet unclear but may be related to detoxification of oxygen-free radicals. Promoter methylation of CYGB in lung, head and neck, and sporadic esophageal cancer has recently become the focus of investigation within our group
Shaw RJ, Liloglou T, Field JK, Risk JM. P096 Cytoglobin: A Candidate Tumor Suppressor Gene Epigenetically Silenced in Head and Neck Cancer. Arch Otolaryngol Head Neck Surg. 2006;132(8):884. doi:10.1001/archotol.132.8.884-b
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