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Poster Presentations: American Head and Neck Society
August 2006

P096 Cytoglobin: A Candidate Tumor Suppressor Gene Epigenetically Silenced in Head and Neck Cancer

Arch Otolaryngol Head Neck Surg. 2006;132(8):884. doi:10.1001/archotol.132.8.884-b

Head and Neck Surgery Unit, Liverpool, England;

University of Liverpool

Background:CYGB is a candidate tumor-suppressor gene on chromosome 17q and is the only gene completely contained within the 42.5-kilobase tylosis with esophageal cancer minimal region. This region is subject to frequent deletions in sporadic esophageal cancer; however, no coding mutations have been demonstrated in patients affected with tylosis. Cytoglobin is a recently described, intracellular globin whose role in cancer is as yet unclear but may be related to detoxification of oxygen-free radicals. Promoter methylation of CYGB in lung, head and neck, and sporadic esophageal cancer has recently become the focus of investigation within our group

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