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Poster Presentations: American Head and Neck Society
August 2006

P119 CD24 Expression Correlates With Response to Cisplatin in Head and Neck Squamous Cell Carcinoma Cell Lines

Arch Otolaryngol Head Neck Surg. 2006;132(8):888. doi:10.1001/archotol.132.8.888-b

Objective: To evaluate the role of CD24 expression regarding cisplatin sensitivity in head and neck squamous cell carcinoma (HNSCC) cell lines.

Design: Cell line study involving University of Michigan Squamous Cell Carcinoma (UM-SCC) cell lines.

Main Outcome Measures: Expression of membrane-bound CD24 was measured by flow cytometry in molecules of equivalent standard fluorochrome (MESF) units. Tumor cell viability in response to cisplatin was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay following CD24 RNA interference or CD24 up-regulation.