Objective: To examine the expression of EphB4 in cigarette-smoking and nonsmoking patients with head and neck squamous cell carcinoma (HNSCC) and to determine its role in tumor growth and metastasis, key factors associated with patient survival.
Design: Expression of EphB4 was determined by Western blot, real-time polymerase chain reaction, and immunohistochemical staining from fresh and archival tissues.
Setting: University medical center otolaryngology–head and neck surgery department.
Sinha UK, Mazhar K, Chinn SB, et al. P192 The Association Between Elevated EphB4 Expression, Smoking Status, and Advanced-Stage Disease in Patients With Head and Neck Squamous Cell Carcinoma. Arch Otolaryngol Head Neck Surg. 2006;132(8):901. doi:10.1001/archotol.132.8.901-b
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