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Poster Presentations: American Head and Neck Society
August 2006

P198 Ezrin and Moesin Cytoplasmic Mislocalization as Potential Predictive Biomarkers: A Tissue Microarray Validation Study

Arch Otolaryngol Head Neck Surg. 2006;132(8):903-904. doi:10.1001/archotol.132.8.903-c

Montefiore Medical Center, Bronx, NY;

Albert Einstein College of Medicine, Bronx;

Johannes Gutenberg University, Mainz, Germany;

University of St Andrews, St Andrews, Scotland

Objectives: The band 4.1 (FERM) proteins, normally adjacent to the cytoplasmic membrane, are part of the molecular scaffolding involved in filamentous actin–based signaling modules. Another FERM protein, NF2 (merlin), has known tumor-suppressor activity. We have previously shown that FERM up-regulation is one of many changes seen in tumor progression. Here, our objective was to validate this by immunohistochemical analysis (IHC) and tissue microarrays (TMAs) in a new prospective cohort.