Objective: Nonsurgical therapy has become a mainstay in the treatment of head and neck squamous cell carcinoma (HNSCC). Despite excellent response rates of the primary tumor to chemoradiotherapy, there is a subgroup of patients with persistent cervical lymphadenopathy requiring salvage neck dissection (SND). Currently, there is no consensus regarding the need for further therapy for patients whose SND specimens reveal active disease. Our objective was to investigate the outcomes of patients undergoing SND following definitive chemoradiation for HNSCC.