Princess Margaret Hospital, Toronto, Ontario;
Ontario Cancer Institute and University Health Network, Toronto;
Mount Sinai Hospital, Toronto;
Princess Margaret Hospital and University Health Network, Toronto;
Ontario Cancer Institute and University Health Network, University of Toronto
Objective: Oral squamous cell carcinomas (OSCCs) are malignant oral cavity tumors that account for 24% of all head and neck cancers. They are the sixth leading cause of cancer death worldwide. In a previous study, we determined the global gene expression profiles of primary OSCCs and identified a subset of deregulated genes that correlated with more advanced-stage tumors. A subset of these genes are involved in signal transduction genetic networks. Our objective is thus to examine the expression of these genes in OSCCs.