Prince of Wales Hospital, Sydney, Australia;
University of New South Wales, Sydney;
Oncology Research Center, University of New South Wales, Sydney
Objective: To establish the correlation of cyclin A1 and mutant p53 in head and neck squamous cell carcinoma (HNSCC), in primary laryngeal SCC, and incidence of second primary tumors (SPTs).
Design: A retrospective cohort of 106 patients with a mean follow-up time of 57.8 months. Using immunohistochemical analysis, we evaluated patients for protein expression of cyclin A1 and mut-p53.
Farhadieh RD, Smee R, Rees CG, Yang L, Russell PJ. P240 Expression of Cell Cycle Regulators as Markers of Field Cancerization and Second Primary Tumors in Larynx Squamous Cell Carcinoma. Arch Otolaryngol Head Neck Surg. 2006;132(8):912–913. doi:10.1001/archotol.132.8.912-c
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