Prince of Wales Hospital, Sydney, Australia;
University of New South Wales, Sydney;
Oncology Research Center, University of New South Wales, Sydney
Objective: To establish the correlation of cyclin A1 and mutant p53 in head and neck squamous cell carcinoma (HNSCC), in primary laryngeal SCC, and incidence of second primary tumors (SPTs).
Design: A retrospective cohort of 106 patients with a mean follow-up time of 57.8 months. Using immunohistochemical analysis, we evaluated patients for protein expression of cyclin A1 and mut-p53.