Background: We have previously identified the pharyngeal constrictors (PC) and the glottic and supraglottic larynx (GSL) as structures whose dysfunction after intensive chemoirradiation is a likely cause of dysphagia, and explored intensity-modulated radiotherapy (IMRT) strategies that spared these structures without compromising target doses (Int J Radiat Oncol Biol Phys. 2004;60:1425-1439). Early results of a clinical trial to validate these findings are presented.