University of Illinois at Chicago;
University of Utah, Salt Lake City;
Northwestern University, Chicago;
Mount Sinai School of Medicine, New York, NY
Objectives: Nitric oxide (NO) plays an important role in cancer growth and metastases. Glutathion-S-transferase (GST-pi) is a protective mechanism against the free radical NO. Correlation between GST-pi and NO levels may indicate that cells can adapt to increasingly hostile NO environments. We hypothesize that tumor cells are better able to adapt and grow in high-NO environments.