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Oral Presentations: American Head and Neck Society
August 2006

S080 Tumor Cells Adapt More Quickly to High Levels of Nitric Oxide (NO) and Become More Malignant in High NO Environment

Arch Otolaryngol Head Neck Surg. 2006;132(8):857. doi:10.1001/archotol.132.8.857-b

University of Illinois at Chicago;

University of Utah, Salt Lake City;

Northwestern University, Chicago;

Mount Sinai School of Medicine, New York, NY

Objectives: Nitric oxide (NO) plays an important role in cancer growth and metastases. Glutathion-S-transferase (GST-pi) is a protective mechanism against the free radical NO. Correlation between GST-pi and NO levels may indicate that cells can adapt to increasingly hostile NO environments. We hypothesize that tumor cells are better able to adapt and grow in high-NO environments.

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