Pathology Quiz Case 2: Diagnosis

Amyloidosis of the larynx is rare, representing fewer than 1% of all benign laryngeal lesions.¹ Subglottic stenosis is usually traumatic in origin. Other benign etiologies include relapsing polychondritis, amyloidosis, sarcoidosis, and Wegener granulomatosis.² Laryngeal amyloid deposits are characterized by extracellular subepithelial proteinaceous deposits, which may have a nodular or diffuse pattern.³ The disease occurs most commonly in the fifth to seventh decades of life, with a male predominance (male-female ratio, 2:1).²