Cytomegalovirus (CMV) is a ubiquitous, opportunistic pathogen. Primary CMV infection occasionally causes a mononucleosis syndrome in immunocompetent patients but is more often asymptomatic. Congenital involvement leads to hearing loss and a host of irreversible neurologic sequelae, whereas the immunocompromised patient can experience chorioretinitis, enteritis, pneumonitis, or central nervous system involvement. Cytomegalovirus–related mucosal ulcerations of the oral cavity and pharynx are not uncommon to this patient population.1