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Clinical Problem Solving: Pathology
March 2007

Pathology Quiz Case 1: Diagnosis

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Arch Otolaryngol Head Neck Surg. 2007;133(3):304-305. doi:10.1001/archotol.133.3.304

Plexiform neurofibromas are benign, slow-growing tumors that are found almost exclusively in patients with NF1. Neurofibromatosis 1 is an autosomal dominant condition that is caused by a defect on chromosome 17, affecting approximately 1 in 4000 births. It is characterized by the presence of numerous cutaneous or subcutaneous neurofibromas, optic gliomas, and café au lait spots. Approximately 17% to 33% of individuals with NF1 present with plexiform neurofibromas.1,2

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