We appreciate the comments from Acar and Karabulut regarding our article “Dornase Alfa as Postoperative Therapy in Cystic Fibrosis Sinonasal Disease.” There have been a number of important additions to the literature regarding the efficacy of dornase alfa therapy since the publication of our work.1,2 These new studies have added to the European and American experience with the clinical use of dornase alfa as an anti-inflammatory agent.
Raia V, Sepe A, Cimmino M, Nardone M, Cavaliere M, Plantulli A, Mazzarella G. Sinonasal Disease and Nasal Saline—Reply. Arch Otolaryngol Head Neck Surg. 2007;133(6):625. doi:10.1001/archotol.133.6.625-b
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