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Clinical Problem Solving: Pathology
May 17, 2010

Pathology Quiz Case 2: Diagnosis

Author Affiliations


Arch Otolaryngol Head Neck Surg. 2010;136(5):525-526. doi:10.1001/archoto.2010.46-b

Diagnosis: Salivary duct carcinoma (SDC) of the parotid gland with mucinous differentiation

Salivary duct carcinoma is a highly aggressive tumor of epithelial origin. Most SDCs (86%) are located within the parotid gland, with the rest being found in the submandibular and intraoral minor salivary glands.1Still, SDCs of the parotid gland are uncommon, representing only 6% to 10% of all parotid neoplasms.2The tumor's name refers to its similarity to ductal carcinoma of the breast.2,3Some authors have alternatively referred to the tumor as cribriform salivary carcinoma of excretory ducts, infiltrating salivary duct carcinoma, or intraductal carcinoma.1Salivary duct carcinoma is found more commonly in males, with a roughly 3:1 predominance over females.1,4Most individuals with SDC are older than 65 years.2

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