[Skip to Content]
[Skip to Content Landing]
Citations 0
Clinical Problem Solving: Pathology
June 21, 2010

Pathology Quiz Case 1: Diagnosis

Author Affiliations


Arch Otolaryngol Head Neck Surg. 2010;136(6):636. doi:10.1001/archoto.2010.66-b

Diagnosis: Ameloblastic carcinoma

Odontogenic malignant neoplasms are rare lesions that arise from dental embryogenic residues. The term ameloblastic carcinomawas introduced by Elzay1in 1982. In the most recent World Health Organization classification,2published in 2005, ameloblastic carcinoma is defined as a rare odontogenic malignant neoplasm that combines the histopathologic features of ameloblastoma with cytologic atypia, with or without metastases. It may develop de novo (primary type) or by malignant transformation of an ameloblastoma (secondary type). The secondary type can be further divided into carcinoma ex intraosseous ameloblastoma and carcinoma ex peripheral (extraosseous) ameloblastoma. The malignant transformation of ameloblastoma may occur either spontaneously or secondary to induction by chemotherapy or irradiation.