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Clinical Problem Solving: Pathology
August 16, 2010

Pathology Quiz Case 2: Diagnosis

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Arch Otolaryngol Head Neck Surg. 2010;136(8):843-844. doi:10.1001/archoto.2010.119-b

Diagnosis: Calcifying fibrous pseudotumor (CFT) of the oral cavity

Calcifying fibrous pseudotumor is a rare soft-tissue lesion that histologically exhibits an abundantly collagenized stroma with psammoma bodies, dystrophic calcifications, and lymphoplasmacytic aggregates. Originally described in 1988 by Rosenthal and Abdul-Karim1as a “childhood fibrous tumor with psammoma bodies,” it was renamed CFT by Fetsch et al2in 1993. This new name emphasized that the entity is not limited to the pediatric population and that the calcifications are not always psammomatous. Fetsch and colleagues argued that these lesions arise as a result of a reactive fibroinflammatory process.

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