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Clinical Problem Solving: Pathology
October 18, 2010

Pathology Quiz Case 2: Diagnosis

Author Affiliations

Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2010

Arch Otolaryngol Head Neck Surg. 2010;136(10):1040-1041. doi:10.1001/archoto.2010.164-b

Sweet syndrome, originally named acute febrile neutrophilic dermatosis, was described in 1964 by Dr Robert Douglas Sweet as a syndrome that presents with an acute onset of fever, leukocytosis, and erythematous plaques composed of neutrophils1as well as with characteristically painful red-brown nodules that are raised and sharply demarcated. These nodules are often located in the head and neck region, although they have been reported to involve lymph nodes,2oral mucosa,3lower extremities,2and genitals.4Although the syndrome may occur in the absence of other known diseases, it is often associated with hematologic (eg, leukemia) and immunologic (eg, rheumatoid arthritis, inflammatory bowel disease) disorders.