A 34-year-old woman presented with right-sided nasal obstruction, intermittent discolored drainage, and facial pressure centered over the right cheek region. She had undergone multiple endoscopic sinus operations, most recently 4 years earlier, as well as rhinoplasty because of functional concerns. Her symptoms of right-sided mucopurulent drainage and pressure temporarily improved after courses of systemic antibiotic therapy. Her symptoms would recur, however, and she had undergone monthly courses of broad-spectrum and culture-directed systemic antibiotic therapy over the preceding 2 years. A review of systems was otherwise noncontributory.