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Clinical Note
May 1999

Sinonasal Mucosa–Associated Lymphoid Tissue Lymphoma

Author Affiliations

From the Departments of Head and Neck Surgery (Drs Babb and Cruz) and Pathology (Dr Puligandla), Kaiser Permanente Medical Center, Oakland, Calif.

Arch Otolaryngol Head Neck Surg. 1999;125(5):585-588. doi:10.1001/archotol.125.5.585

Mucosa-associated lymphoid tissue (MALT) is a specialized form of lymphoid tissue that may be acquired at sites in response to chronic inflammation. Most low-grade, B-cell, non-Hodgkin lymphomas that occur at extranodal sites derive from acquired MALT. Confusing and overlapping terms have been used to describe these lymphomas, but immunohistochemical advances now allow more precise subtyping. Our review of the literature yielded only 2 previous reports of sinonasal MALT-derived lymphoma, and we report an additional case in a patient with a history of chronic sinusitis. Current developmental theories of MALT-derived lymphomas are discussed. In addition, we review the clinical, histologic, and immunophenotypic features of MALT-derived lymphomas.

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