The Gradenigo syndrome consists of a definite entity, occurring in the course of acute otitis media, and presenting certain clinical symptoms, the most predominating of which is paralysis of the abducens nerve. The condition was described in 1904 by Gradenigo, whose careful studies and observations threw valuable light on a hitherto obscure subject, and one not commonly met. Seldom will an otologist see more than three or four cases in a busy lifetime. However, when it does occur, there is nothing that will cause more anxiety and concern. Most textbooks dismiss the subject with a few lines, while a great many fail to mention it. Since Gradenigo's excellent presentation twenty years ago, there has been less than 200 cases reported on both sides of the Atlantic. In 1924, William Harden Sears wrote a splendid résumé of the subject including his own case report, covering the ground very thoroughly.
DINTENFASS H. GRADENIGO'S SYNDROME IN MASTOID DISEASE: REPORT OF A CASE. Arch Otolaryngol. 1926;3(4):349–352. doi:10.1001/archotol.1926.00580010375004
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