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Article
October 1926

PHENOBARBITAL IN THE PROPHYLAXIS AND TREATMENT OF ACUTE COCAINE INTOXICATIONS: A PRELIMINARY REPORT OF ITS CLINICAL TRIAL

Author Affiliations

CHICAGO
From the clinic of Drs. Joseph C. Beck and Harry L. Pollack.

Arch Otolaryngol. 1926;4(4):304-306. doi:10.1001/archotol.1926.00590010326005
Abstract

The use of cocaine in rhinologic practice is so generalized and of such frequent occurrence as to present great potentialities for overdosage and intoxications. It is a matter of common experience for one doing extensive intranasal surgery to be confronted by a so-called cocaine "reaction," and this is especially true when using "flake" anesthesia. Often people are encountered who exhibit an idiosyncrasy to the drug, and who, consequently, are susceptible even to minute amounts.

The intoxication is manifested usually by loquacity, restlessness, tremor and cardiac palpitation. There is also present a peculiar writhing of the tongue and the face. This hyperactivity of the lingual and facial musculature may become so troublesome as to interfere seriously with the necessary intranasal manipulations. Not rarely, the symptoms of mild intoxication noted in the foregoing may progress to those associated with profound depression, combined with cold clammy sweat, pallor and even syncope which

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