It is a well known fact that the action of cocaine and epinephrine on the blood pressure is synergistic. It has been shown that this synergy between cocaine and epinephrine includes toxicity. Moderate amounts of epinephrine markedly increase the poisonous effects of cocaine.1
Chen and Schmidt2 showed that ephedrine possesses most of the properties of epinephrine, in that it stimulates the sympathetic nervous system. They showed that the action is chiefly peripheral, but that with large doses it extends to central stimulation. The drug differs from epinephrine in that it maintains an increased blood pressure for a longer time.
Chen and Schmidt3 proved that ephedrine stimulates the stellate ganglion.
Chen and Meek 4 demonstrated synergistic action between ephedrine and epinephrine, as far as the action on the blood pressure is concerned.
If ephedrine produces changes identical with those produced by epinephrine, its action on the blood pressure
ROSS EL. EPHEDRINE AND COCAINE SYNERGY. Arch Otolaryngol. 1927;5(6):509–513. doi:10.1001/archotol.1927.00600010539005
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