Malignant disease of the larynx occurs in 5 per cent of all malignant tumors and may be classified as follows: carcinoma, 98 per cent; sarcoma, 2 per cent. Of the carcinomas, 96 per cent are squamous cell and extremely malignant, varying considerably in degree; 2 per cent are basal cell carcinoma, 1 per cent papillary carcinoma and 1 per cent adenocarcinoma. The last three types are less malignant than the squamous cell carcinoma.
From a surgical and prognostic standpoint, the exact location of cancer in or about the larynx is of extreme importance. Clinically, the three recognized classifications, based on the location and on the extent of the disease, are: extrinsic, intrinsic and borderline intrinsic.
Extrinsic cancer rarely gives warning of its presence until well advanced, since cancer is a painless disease in this situation prior to the late ulcerative period, and since it does not at first alter the
MACKENTY JE. LARYNGEAL CANCER: EARLY DIAGNOSIS AND TREATMENT. Arch Otolaryngol. 1929;9(3):237–244. doi:10.1001/archotol.1929.00620030255001
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