Schultz,1 in 1922, reported six cases of angina agranulocytosis, in all of which the disease was characterized by an acute infection of the mouth or throat, a low white cell count with a marked reduction or absence of the granular cells, high fever, great prostration and a rapidly fatal course, death occurring in from three to four days. All the patients were middle-aged women who had been in good health before the onset of this disease. The tonsils and pharynx were acutely inflamed and became ulcerated and covered with a grayish exudate. There was some enlargement of the cervical lymph glands, and the liver and spleen were enlarged in three of the patients. They were jaundiced but did not have any hemorrhagic spots.
Since this report, many more cases have been reported. In 1927, Kastlin made a careful review of the literature; he found forty-three cases reported and added
POTTS JB. ANGINA AGRANULOCYTOSIS. Arch Otolaryngol. 1929;9(3):256–265. doi:10.1001/archotol.1929.00620030274004
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